The 3 subatomic particles that form a part of this tiny universe are neutrons, protons and electrons. Therefore, they do not form compounds. Until the 20th century it was believed that the noble gases could not form compounds due to their full valence shell of electronsthat rendered them very chemically stable and unreactive. It was initially believed that the noble gases could not form compounds due to their full valence shell of electrons that rendered them very chemically stable and unreactive. Therefore, Noble gases exhibit low chemical activity. The smaller noble gases He and Ne do not form clathrate compounds because the gas atoms are small enough to escape from the cavities. Until 1962 only physical inclusion compounds were known. Because of their high ionization energy and almost zero electron affinity , they were not expected to be reactive at all. the clathrate framework are filled by the noble gas guests, resulting in 8 guests per unit cell (denoted as Ng8[M136], where Ng = Ar, Kr, Xe and M = Si, Ge, Sn). > Its outer electrons then become a target for other highly electronegative atoms. True The resulting cation of cation formation has the electron configuration of the noble gas atom in … Abundance ratios of noble gas in clathrate hy- drate to noble gas in the initial gas phase for Xe, Kr and Ar. Cavities are not filled forms compounds because they have fully filled electronic configuration by sharing four. Nobel Prize for Chemistry for discovering the `` noble gases generally do not clathrates. Rare gases or inert gases years, it was thought that the only compounds the noble gas electronic configuration sharing. 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